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DNA Primase (Primase)

Target: Primase
Molecular classification: Enzyme, RNA Polymerase

Overview

DNA primase is an essential enzyme that synthesizes short RNA primers on single-stranded DNA templates during DNA replication initiation. These primers provide the 3'-hydroxyl group necessary for DNA polymerases to begin elongation. In bacteria, it forms a complex with helicase called the primosome, while in eukaryotes and archaea, it's part of a heterodimeric complex often associated with Pol α-primase. Viral primases are targets for antiviral drug development.

Other names: DnaGPRIM1PRIM2PriSPriL

Mechanism of action

Inhibition of RNA primer synthesis, thereby blocking DNA replication

Biological functions

DNA replication initiationRNA primer synthesisRegulation of replication fork progression

Disease associations

Viral infection

Safety considerations

Potential for off-target effects on host polymerases (if not selectively targeted)Development of resistance to inhibitors

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