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DNA repair and recombination protein RAD54B (RAD54B)
- Target
- RAD54B
- Molecular classification
- Enzyme, DNA helicase, SWI2/SNF2 family, DEAD-like helicase superfamily
01
Overview
DNA repair and recombination protein RAD54B (RAD54B) is an ATP-dependent DNA helicase belonging to the SWI2/SNF2 and DEAD-like helicase superfamilies, essential for homologous recombination and double-strand DNA break repair in human cells[1][3][4]. RAD54B interacts with RAD51 and DMC1, promoting and stabilizing DNA strand pairing during recombination and cell division[1][4]. The gene is highly expressed in testis and spleen, suggesting critical roles in meiotic and mitotic recombination. RAD54B functions as an accessory factor in DNA repair, enabling genomic stability, and its loss or mutation is linked to several cancer types, including colorectal and breast cancer[4]. While not commonly targeted by approved drugs, RAD54B is considered a potential therapeutic target for interventions seeking to modulate DNA repair pathways in cancer therapy and other diseases characterized by genomic instability[3][4].
- Other names
- RAD54 homolog BRDH54RAD54 homolog B (S. cerevisiae)DNA repair and recombination protein RAD54B
02
Biological functions
DNA repairHomologous recombinationATP-dependent DNA unwindingGenomic stabilityCell division
03
Disease associations
CancerGenetic disordersOther genomic instability conditions
04
Safety considerations
Potential risk of interfering with genomic stability if targetedOff-target effects in therapies involving DNA repair modulation
05
Biomarkers
Somatic mutation/deletion in several cancers (e.g., colorectal cancer, breast cancer)
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