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DNA Repair Process
- Molecular classification
- Enzyme, DNA maintenance, Signaling pathway
01
Overview
DNA repair process refers to a collection of multiple pathways. It is not a single molecule but an array of tightly regulated molecular systems safeguarding genome stability through diverse enzymatic activities tailored for different types of genetic lesions. These pathways include Direct Reversal, Base Excision Repair (BER), Nucleotide Excision Repair (NER), Mismatch Repair (MMR), Homologous Recombination (HR), and Non-Homologous End Joining (NHEJ).
- Other names
- DNA repair mechanismsGenome maintenanceError correction pathways
02
Mechanism of action
Varies depending on the specific repair pathway and drug; e.g., PARP inhibitors block PARP-mediated DNA repair, leading to synthetic lethality in cells with HR deficiency.
03
Biological functions
Genome stabilityMutation preventionCell cycle regulationDNA replication fidelity
04
Disease associations
CancerAgingGenetic instability syndromesNeurodegenerative diseases
05
Safety considerations
Off-target effects of DNA repair inhibitorsDevelopment of resistance to DNA repair inhibitorsPotential for increased mutagenesis or genomic instability with certain repair inhibitors
06
Interacting drugs
PARP inhibitors
1 more in the full profile.
07
Biomarkers
BRCA1/2 mutations (for PARP inhibitor sensitivity)Microsatellite instability (MSI)Tumor Mutational Burden (TMB)Expression levels of DNA repair proteins
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