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Target intelligence / Profile preview
DNA repair protein RAD51 homolog 1 (RAD51)
- Target
- RAD51
- Molecular classification
- Enzyme, Recombinase, ATPase
01
Overview
RAD51 is an ATP-dependent recombinase essential for homologous recombination-mediated repair of double-strand DNA breaks. It forms a nucleoprotein filament on single-stranded DNA, facilitating homology search and strand invasion. Dysregulation or mutation of RAD51 is associated with cancer and genomic instability disorders, making it a potential therapeutic target.
- Other names
- RAD51ARECABRCC5FANCRHRAD51
02
Mechanism of action
Inhibition of homologous recombination
03
Biological functions
Homologous recombination-mediated double-strand break repairReplication fork protection under replication stressMeiotic chromosome segregationDNA repair
04
Disease associations
CancerFanconi anemiaGenomic instability
05
Safety considerations
Overexpression linked to cancerPotential for synthetic lethality approaches to cause off-target effects
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