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Target intelligence / Profile preview
DNA replication and sister chromatid cohesion 1 (DSCC1)
- Target
- DSCC1
- Molecular classification
- Other (Replication factor C complex subunit; DNA replication and cohesion establishment factor)
01
Overview
DNA replication and sister chromatid cohesion 1 (DSCC1) is a protein that is a critical component of the alternative replication factor C (RFC) complex known as the CTF18-RFC complex, which includes CTF18, DSCC1, and CTF8. This complex is responsible for loading the proliferating cell nuclear antigen (PCNA) onto DNA during the S phase of the cell cycle. DSCC1's main functions are to support proper DNA replication, regulate replication fork progression, and ensure the establishment of sister chromatid cohesion necessary for accurate chromosome segregation. DSCC1 is overexpressed in several cancer types, where it promotes cell proliferation, tumor growth, and resistance to apoptosis, making it a potential prognostic biomarker and therapeutic target. Gene amplification and high expression levels of DSCC1 correlate with adverse prognosis in liver, breast, and colorectal cancers. No approved drugs are known to specifically target DSCC1 at this time.
- Other names
- DCC1Sister chromatid cohesion protein DCC1hDCC1MGC5528Defective in sister chromatid cohesion protein 1 homologdefective in sister chromatid cohesion homolog 1 (S. cerevisiae)UNQ9337/PRO34008CTF18-DSCC1-CTF8 module
02
Biological functions
DNA replicationSister chromatid cohesionCell cycle progressionChromosome segregationReplication fork stabilityCell proliferation
03
Disease associations
CancerTumor proliferationHepatocellular carcinomaBreast carcinomaColorectal cancer
04
Safety considerations
Potential risk of disrupting genome stability due to essential role in DNA replication and chromatid cohesion
05
Biomarkers
Pan-cancer prognostic biomarker (for tumor proliferation and poor prognosis)
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