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DNA Replication Machinery (Replisome)

Target: Replisome
Molecular classification: Multiprotein Complex

Overview

The DNA replication machinery, also known as the replisome, is a multi-protein complex responsible for duplicating the cell’s genetic material before cell division. This complex includes DNA polymerases, helicase, primase, single-stranded binding proteins, topoisomerases, and sliding clamps, working together to ensure accurate and efficient DNA replication.

Other names: Replication factoryReplication complexReplication system

Biological functions

DNA replicationGenome maintenanceCell division

Disease associations

CancerGenetic disorders

Safety considerations

Replication errors leading to mutationsDysregulation leading to uncontrolled cell proliferation

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