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DNA Synthesis (Chain Termination) (N/A)
- Target
- N/A
- Molecular classification
- Enzymatic Process, DNA Replication, Molecular Biology Technique
01
Overview
DNA synthesis (chain termination) is a process utilized to halt DNA strand elongation during replication or sequencing. It relies on the use of dideoxynucleotides (ddNTPs), which lack a 3'-hydroxyl group, causing termination of the DNA chain upon incorporation by DNA polymerase. The Sanger sequencing method exemplifies this process. Furthermore, chain terminators find utility as antiviral agents and molecular probes for investigating enzyme mechanisms.
- Other names
- Sanger SequencingChain Termination MethodddNTP IncorporationDideoxy Sequencing
02
Mechanism of action
Chain termination via incorporation of dideoxynucleotides (ddNTPs) into the growing DNA strand, preventing further elongation due to the absence of a 3'-OH group.
03
Biological functions
DNA SequencingDNA Replication TerminationAntiviral Action (indirectly, via chain-terminating drugs)Enzyme Mechanism Studies
04
Disease associations
Viral Infection (therapeutic applications of chain-terminating nucleosides)
05
Safety considerations
Potential for off-target effects with antiviral nucleoside analogsDrug resistance development in viruses
06
Interacting drugs
Acyclovir
4 more in the full profile.
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