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Target intelligence / Profile preview
DNA Synthesis Enzyme Complex (Replisome)
- Target
- Replisome
- Molecular classification
- Enzyme Complex, Protein Complex
01
Overview
The DNA synthesis enzyme complex, or replisome, is a multi-protein assembly responsible for accurate and efficient DNA replication during cell division. It orchestrates the unwinding of double-stranded DNA and synthesizes new complementary strands using existing strands as templates. Key components include DNA polymerase, helicase, primase, single-strand binding protein, topoisomerase/gyrase, sliding clamp, clamp loader, and ligase.
- Other names
- DNA Replication Complex
02
Mechanism of action
Inhibition of DNA synthesis by targeting individual enzymes within the complex, leading to chain termination or replication fork stalling.
03
Biological functions
DNA ReplicationGenome DuplicationCell Division
04
Disease associations
Cancer (indirectly, through replication errors)Genetic Disorders (indirectly, through replication errors)
05
Safety considerations
Off-target effects on other DNA polymerasesPotential for drug resistanceToxicity due to disruption of normal DNA replication
06
Interacting drugs
Nucleoside analogs (e.g., AZT, acyclovir)
3 more in the full profile.
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