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Target intelligence / Profile preview
DNA Synthesis in Keratinocytes (N/A)
- Target
- N/A
- Molecular classification
- Cellular process, DNA replication
01
Overview
DNA synthesis in keratinocytes is the process by which these epidermal cells replicate their DNA, primarily during cell proliferation and before cell division. This process is crucial for skin growth, repair, and regeneration. Key processes involved include DNA replication during proliferation, chromatin remodeling during differentiation, and nuclear condensation/degradation during terminal differentiation involving DNases like DNase1L2, DNase2 and TREX2. Epigenetic regulation through DNA methylation/hydroxymethylation also plays a role. Dysregulation can contribute to skin disorders like parakeratosis and psoriasis.
- Other names
- Keratinocyte DNA replicationDNA replication in epidermal cells
02
Mechanism of action
N/A
03
Biological functions
Cell proliferationSkin growthSkin repairDNA replicationCell divisionDifferentiationNuclear degradation
04
Disease associations
ParakeratosisPsoriasisSkin disorders
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