DNA Synthesis via Nucleoside Analog Incorporation

DNA synthesis via nucleoside analog incorporation is a process where synthetic nucleoside analogs are incorporated into newly synthesized DNA strands during replication or repair. These analogs disrupt normal DNA elongation and function, often acting as chain terminators or causing replication fork stalling, leading to cell cycle arrest, DNA damage responses, and apoptosis. This mechanism is utilized in antiviral and cancer chemotherapy.

Other names

Nucleoside Analog IncorporationNucleotide Analog IncorporationDNA Replication Inhibition by Nucleoside AnalogsDNA Synthesis Inhibition

Nucleoside analogs are phosphorylated, incorporated into DNA, and cause chain termination or stalled replication forks, leading to cell cycle arrest and apoptosis.