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Target intelligence / Profile preview
DNA synthesis inhibition via nucleoside analog incorporation
- Molecular classification
- Other
01
Overview
DNA synthesis inhibition via nucleoside analog incorporation is a mechanism by which certain drugs disrupt the replication of DNA in cells. Nucleoside analogs are structurally similar to natural nucleosides but with critical modifications that interfere with normal DNA chain elongation. These analogs are incorporated into newly synthesized DNA strands, causing chain termination and ultimately leading to cell cycle arrest and apoptosis. This mechanism is exploited in antiviral and anticancer therapies.
- Other names
- Nucleoside analog incorporationDNA replication inhibition by nucleoside analogsChain termination by nucleoside analogs
02
Mechanism of action
Incorporation of nucleoside analogs into nascent DNA strands, leading to premature chain termination and inhibition of DNA synthesis.
03
Biological functions
DNA replication inhibitionCell cycle arrestApoptosis induction
04
Disease associations
CancerViral infection
05
Safety considerations
Bone marrow suppressionOff-target toxicityMitochondrial toxicity
06
Interacting drugs
Trifluridine
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