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Target intelligence / Profile preview
Nuclear genomic DNA during synthesis/replication (DNA)
- Target
- DNA
- Molecular classification
- Nucleic Acid, Genome
01
Overview
Nuclear genomic material—specifically interfering with machinery responsible for accurate duplication/synthesis—by inducing structural lesions that overwhelm cellular coping mechanisms leading predominantly to apoptotic death in susceptible tumor populations. Platinum-based chemotherapies target DNA, leading to the formation of DNA adducts (intra- and inter-strand crosslinks) which disrupt DNA replication and transcription.
- Other names
- dsDNAGenomic DNADNA Synthesis MachineryMitosis Machinery
02
Mechanism of action
Formation of intra/interstrand crosslinks → blocks replication/transcription
03
Biological functions
ReplicationTranscriptionCell CycleGenetic Information Storage
04
Disease associations
Cancer
05
Safety considerations
Drug resistanceOff-target effects in rapidly dividing normal cells (e.g., bone marrow, hair follicles)NephrotoxicityNeurotoxicity
06
Interacting drugs
Cisplatin
2 more in the full profile.
07
Biomarkers
Pre-replicative complex assembly proteinsReplicative helicase activityCdc7NER pathway proteinsBER pathway proteinsMMR pathway proteinsHR pathway proteinsNHEJ pathway proteins
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