DNA Synthesis Pathway

The DNA synthesis pathway encompasses the biochemical events and molecular interactions that result in the formation of new DNA molecules. This process is crucial for cell division, genetic inheritance, and DNA repair. It involves initiation at origins of replication, primer synthesis by primase, elongation by DNA polymerases, and termination/processing to seal newly synthesized fragments. Key enzymes include helicases, single-strand binding proteins, primases, DNA polymerases, topoisomerases, and ligases. The pathway is tightly regulated to ensure accurate duplication and prevent uncontrolled cell growth. Disruption of this pathway is implicated in various diseases, particularly cancer.

Various; depends on specific drug and its target within the pathway. Examples include inhibition of DNA polymerase, topoisomerase, or nucleotide synthesis.