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DNA Topoisomerase 2 (Top2)
- Target
- Top2
- Molecular classification
- Enzyme, Topoisomerase, Type II Topoisomerase
01
Overview
DNA Topoisomerase 2 (Top2) is a type II topoisomerase enzyme that manages DNA topology by introducing transient double-strand breaks, allowing DNA segment passage, and religating the strands. It is essential for replication, transcription, recombination, and chromosome segregation. Top2 is a target for anticancer drugs that stabilize the cleavage complex, causing cell death, but this can lead to safety concerns like secondary malignancies.
- Other names
- Topoisomerase IIDNA gyrase (in bacteria)TOP2ATOP2B
02
Mechanism of action
Topoisomerase poisons stabilize the Top2-DNA cleavage complex, leading to DNA double-strand breaks and cell death.
03
Biological functions
DNA topology managementSupercoil relaxationDecatenationChromosome segregationDNA replicationTranscriptionRecombinationGenome organization
04
Disease associations
Cancer
05
Safety considerations
Secondary malignanciesCardiotoxicityOff-target effects
06
Interacting drugs
Etoposide
1 more in the full profile.
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