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Target intelligence / Profile preview
DNA topoisomerase 2-binding protein 1 (TOPBP1)
- Target
- TOPBP1
- Molecular classification
- Scaffold protein, DNA repair protein, DNA replication protein
01
Overview
DNA topoisomerase 2-binding protein 1 (TOPBP1) is a multi-domain scaffold protein essential for coordinating protein complexes involved in DNA replication, DNA repair, and cell cycle checkpoint activation[2][3][1]. It is characterized by the presence of nine BRCT domains, which facilitate phosphorylation-dependent interactions with numerous proteins, including DNA topoisomerase II, BRCA1, RAD9, MDC1, and ATR[1][2]. TOPBP1 is crucial for activation of the ATR kinase in response to DNA damage, bridging accessory factors and promoting recruitment of repair proteins to damage sites[3][2]. Through its regulatory and structural roles, TOPBP1 is central to genome integrity. Abnormal expression or mutations in TOPBP1 are linked to cancer and other disease states[2].
- Other names
- DNA topoisomerase II binding protein 1TOPBP1KIAA0259TopBP1TOP2BP1Dpb11DNA topoisomerase II-beta-binding protein 1topoisomerase (DNA) II binding protein 1
02
Biological functions
DNA damage repairDNA replicationCell cycle checkpoint activationTranscriptional regulation
03
Disease associations
Cancer (breast cancer, glioblastoma, non-small cell lung cancer, sarcomas)Pulmonary hypertension
04
Safety considerations
Potential involvement in cancer pathogenesis (e.g., breast cancer)essential for genome stabilitydisruption may lead to genome instability or increase cancer risk
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