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Bacterial Topoisomerase IV (Topo IV)
- Target
- Topo IV
- Molecular classification
- Enzyme, DNA Topoisomerase, Type IIa Topoisomerase
01
Overview
Bacterial topoisomerase IV is a type II DNA topoisomerase essential for managing bacterial chromosome topology during replication and segregation. It is a heterotetramer (ParC2ParE2) that primarily functions to decatenate interlinked daughter chromosomes after DNA replication and relax positive supercoils. It is a validated antibacterial drug target, with fluoroquinolones and novel bacterial topoisomerase inhibitors (NBTIs) inhibiting its activity.
- Other names
- Topo IVDNA topoisomerase 4
02
Mechanism of action
ATP-dependent double-strand breakage/passage/rejoining; inhibition of DNA decatenation and relaxation of positive supercoils
03
Biological functions
DNA DecatenationRelaxation of positive supercoilsChromosome segregationDNA replication
04
Disease associations
Infection
05
Safety considerations
Antibiotic resistance developmentOff-target effects on human topoisomerases (potential anticancer applications, but also potential toxicity)
06
Interacting drugs
Fluoroquinolones
2 more in the full profile.
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