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DNA Topoisomerase I, Mitochondrial (Top1mt)
- Target
- Top1mt
- Molecular classification
- Enzyme, DNA topoisomerase
01
Overview
DNA topoisomerase I, mitochondrial (Top1mt), is an enzyme localized exclusively to mitochondria in human cells. It plays a critical role in maintaining the topology of mitochondrial DNA (mtDNA) by relieving supercoiling and torsional stress that arise during mtDNA replication and transcription. This function is essential for proper mitochondrial genome maintenance, gene expression, and overall cellular energy metabolism. Altered expression levels of TOP1MT have been observed in various cancers, and loss-of-function mutations can lead to increased oxidative stress, impaired energy metabolism, and heightened sensitivity to additional cellular stresses. Pharmacological inhibition impairs T cell metabolic fitness by inducing mtDNA damage.
- Other names
- TOP1MT
02
Mechanism of action
Inhibition of DNA topoisomerase I
03
Biological functions
Regulation of mitochondrial DNA topologyMitochondrial transcription regulationMitochondrial DNA replicationMaintenance of mitochondrial genome stability
04
Disease associations
CancerCardiovascular diseaseInfection
05
Safety considerations
Potential for mitochondrial toxicity upon inhibitionIncreased oxidative stress
06
Interacting drugs
Camptothecin
1 more in the full profile.
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