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Target intelligence / Profile preview
DNA topoisomerase IV subunit B (ParE)
- Target
- ParE
- Molecular classification
- Enzyme, Type II topoisomerase, DNA topoisomerase
01
Overview
DNA topoisomerase IV subunit B (ParE) is a crucial component of bacterial type II topoisomerases. It forms part of the heterotetrameric enzyme complex, which is essential for chromosome segregation and decatenation of daughter chromosomes after DNA replication. ParE contains the ATP-binding site and is a target for antibiotics such as coumarins and cyclothialidines. Mutations in parE can confer antibiotic resistance.
- Other names
- nfxDECK3021JW2998
02
Mechanism of action
Inhibits DNA topoisomerase IV activity by binding to the ATP-binding site of the ParE subunit, preventing ATP hydrolysis and DNA strand passage.
03
Biological functions
DNA decatenationDNA relaxationChromosome segregation
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Development of antibiotic resistanceCross-resistance to multiple antibiotics
06
Interacting drugs
Coumarins (Novobiocin)
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