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DNAAF3 antisense RNA 1 (DNAAF3-AS1)
- Target
- DNAAF3-AS1
- Molecular classification
- Long noncoding RNA (lncRNA), Other
01
Overview
DNAAF3 antisense RNA 1 (DNAAF3-AS1) is a human long noncoding RNA (lncRNA) gene located on chromosome 19. It is transcribed in the antisense orientation relative to the DNAAF3 gene, which encodes a protein critical for axonemal dynein assembly and ciliary function[2][3][4]. DNAAF3-AS1 has been classified as a cis-repressor lncRNA, meaning it can repress the expression of neighboring genes, potentially acting on the same chromosome region where it is transcribed[6]. Diseases associated with DNAAF3-AS1 include ciliary dyskinesia, both primary and type 2, which are likely linked to its genomic context and potential regulatory impact on DNAAF3 or related genes[3]. There are no known drug interactions, no established roles as a biomarker, and no evidence that DNAAF3-AS1 itself is a direct therapeutic target.
- Other names
- GC19P055689GC19P056057GC19P056531GC19P057134GC19P057945GC19P060247GC19P060779GC19P061335GC19P062786GC19P064559GC19P067599GC19P070686GC19P073812GC19P077157GC19P080597GC19P084208GC19P090479GC19P096929GC19P104029GC19P114012GC19P124004GC19P133998GC19P143736
02
Biological functions
Cis-repression (transcriptional regulation)
03
Disease associations
Ciliary dyskinesia (Primary ciliary dyskinesia)
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