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DNABII Protein Family (DNABII)
- Target
- DNABII
- Molecular classification
- Nucleoid-associated protein (NAP), DNA-binding protein
01
Overview
The DNABII protein family is a group of nucleoid-associated proteins found in all eubacteria. Key members include Integration Host Factor (IHF) and Histone-like protein HU. These proteins are critical for bacterial nucleoid structure and play a vital role in stabilizing extracellular DNA lattices within biofilms. They are considered therapeutic targets for anti-biofilm therapies, with antibodies showing promise in disrupting and dispersing mature biofilms.
- Other names
- Integration Host Factor (IHF)Histone-like protein HU
02
Mechanism of action
Antibody targeting disrupts DNABII protein function, leading to biofilm destabilization and dispersal
03
Biological functions
Nucleoid structuringDNA condensationBiofilm stabilizationExtracellular DNA lattice formation
04
Disease associations
InfectionBiofilm-associated infectionsCystic fibrosis
05
Safety considerations
Potential for off-target effects due to ubiquitous expression in eubacteriaDevelopment of resistance mechanisms by bacteria
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