DnaJ heat shock protein family (Hsp40) member C22 (DNAJC22)

DnaJ heat shock protein family (Hsp40) member C22 (DNAJC22) is a molecular chaperone that may act as a co-chaperone within the Hsp40 family. The protein is predicted to localize to membranes and is involved in assisting protein folding, potentially by supporting Hsp70 chaperone activities. Expression is detected in multiple tissues, including brain, gut, liver, and kidney in mouse models, and RNA/protein is found in various human cancers, though its precise functional role in cancer is not fully defined. DNAJC22 has been linked to wrinkly skin syndrome, as an associated gene, but no direct causative or therapeutic implication has been established. There are currently no known small molecules, inhibitors, antibodies, or approved drugs that directly target DNAJC22 for therapeutic purposes. The gene product shares homology with other DnaJ/Hsp40 proteins and interacts with various heat shock proteins, including Hsp70 family members, supporting general cellular protein quality control mechanisms. DNAJC22 is categorized as a chaperone and co-chaperone, not a classical receptor, enzyme, transporter, or transcription factor, and does not currently meet broad criteria for being a direct therapeutic target. It is not misspelled or otherwise incorrect, and the currently available information is based on established genetic, genomic, and proteomic databases.

Other names

DnaJ homolog subfamily C member 22DNAJC22wusFLJ13236wurst homolog (Drosophila)DnaJ (Hsp40) homolog, subfamily C, member 22wurst homolog2810451A06Rik