DnaJ heat shock protein family (Hsp40) member C28 (DNAJC28)

DnaJ heat shock protein family (Hsp40) member C28 (DNAJC28) is a protein-coding gene located on chromosome 21, encoding a 388-amino-acid protein that functions as a member of the DnaJ (Hsp40) co-chaperone family[2][3][5][6]. The protein contains a conserved N-terminal J-domain, essential for interaction with Hsp70 chaperones involved in ATPase regulation and protein folding[2][3][10]. DNAJC28 is thought to facilitate proper folding of newly synthesized proteins, act as a molecular chaperone to prevent aggregation, contribute to protein quality control, and participate in vesicle transport processes within the Golgi[1][2][7]. There is no current evidence that DNAJC28 itself is a therapeutic target; it is classified as a molecular chaperone, not a receptor, enzyme, transporter, or traditional drug target[3][6][11]. Disease associations are not well defined, though variants have been annotated with rare neuronopathy phenotypes[3]. There are no known drugs targeting DNAJC28, and no established biomarker or safety concerns linked specifically to this gene[3][10][12].

Other names

C21orf55C21orf78DnaJ homolog subfamily C member 28Orf28DJC28DJC28_HUMAN