DnaJ heat shock protein family member A3 (DNAJA3)

DnaJ heat shock protein family member A3 (DNAJA3, also known as Tid1) is a mitochondrial molecular chaperone of the DNAJ/Hsp40 family. DNAJA3 partners with Hsp70 chaperones to regulate protein folding, degradation, and assembly of multiprotein complexes—critical for mitochondrial biogenesis and maintenance of membrane potential and DNA integrity. It exists as two isoforms with distinct apoptotic effects: one promotes apoptosis through cytochrome C release, while the other inhibits apoptosis. DNAJA3 interacts with key cancer-related proteins such as p53 and ErbB2, functioning as a tumor suppressor, and may modulate cellular proliferation and survival signals. Disease associations include various cancers, neurodegenerative diseases, and inflammatory conditions. The protein is crucial for proper mitochondrial and cellular homeostasis, with its expression and function influencing disease outcomes and therapeutic strategies.

Other names

Tid1TID1HCA57hTid-1Tid1-STid1-LDNJA3_HUMANtumorous imaginal disc 1tumorous imaginal discs protein Tid56 homologDnaJ protein Tid-1

Promotion of apoptosis via cytochrome C release and caspase activation; Tumor suppression by interaction with p53 and downregulation of oncogenic ErbB2 receptors; Regulation of EGFR/AKT signaling pathways; Support of protein folding in mitochondria