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Target intelligence / Profile preview
DNAJ heat shock protein family member B1-protein kinase cAMP-dependent catalytic subunit alpha fusion protein (DNAJB1-PRKACA fusion protein)
- Target
- DNAJB1-PRKACA fusion protein
- Molecular classification
- Fusion Protein, Chimeric Protein, Kinase, Molecular Chaperone
01
Overview
The DNAJ heat shock protein family member B1-protein kinase cAMP-dependent catalytic subunit alpha fusion protein is a chimeric oncoprotein associated with fibrolamellar hepatocellular carcinoma (FL-HCC). This fusion results from a deletion on chromosome 19, joining the first exon of DNAJB1 to exons 2–10 of PRKACA. The fusion creates a functional chimeric enzyme with altered regulatory control, leading to increased cAMP-dependent signaling and tumorigenesis. The presence of this fusion is pathognomonic for FL-HCC and serves as a diagnostic biomarker and potential therapeutic target.
- Other names
- DNAJB1-PRKACAChimeric DnaJ-PKAHSP40-PKA Fusion Protein
02
Mechanism of action
Inhibiting kinase activity of the fusion protein, disruption of protein-protein interactions.
03
Biological functions
Protein foldingStress responseSignal transduction via cAMPSerine/threonine kinase activityCell proliferationOncogenesis
04
Disease associations
CancerFibrolamellar Hepatocellular Carcinoma
05
Safety considerations
Potential for off-target effects with kinase inhibitorsDevelopment of resistance to targeted therapies
06
Biomarkers
DNAJB1-PRKACA fusion transcript (diagnostic)DNAJB1-PRKACA fusion protein (diagnostic)
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