DnaJ heat shock protein family member C18 (DNAJC18)

DnaJ heat shock protein family member C18 (DNAJC18) is part of the Hsp40/DnaJ family, specifically the type III subfamily, distinguished by a J domain but lacking the typical G/F-rich or cysteine-rich regions found in other subfamilies[2]. It encodes a cytosolic protein, functioning primarily as a chaperone or co-chaperone involved in cellular response to misfolded proteins and maintenance of proteostasis[1][4][7]. It interacts with Hsp70 proteins to regulate their ATPase activity and is suggested to participate in processes such as cellular stress response, protein folding, and possibly in germ cell development (spermatogenesis), particularly in the testis[2]. DNAJC18 is located in the endoplasmic reticulum membrane and cytoplasm, and may play a role in viral infection pathways, notably aiding the penetration of certain viruses, such as polyomavirus, across the ER membrane[1][2][4]. There are no current data linking DNAJC18 to interacting drugs, known therapeutic targeting, or established biomarker or safety concerns[1][4][7].

Other names

DnaJ homolog subfamily C member 18DJC18MGC29463DnaJ (Hsp40) homolog, subfamily C, member 18dnaJ homolog subfamily C member 18

Not applicable; no targeted drugs currently known Extrapolated function: modulates Hsp70 activity and assists in regulated unfolding or translocation of proteins during stress and viral infection