DnaJ heat shock protein family member C5 beta (DNAJC5B)

DnaJ heat shock protein family member C5 beta (DNAJC5B) is a member of the DNAJ (Hsp40) family of proteins, functioning as a co-chaperone that regulates the proper folding of other proteins via interaction with Hsp70 heat shock proteins. The protein is characterized by an N-terminal DNAJ domain, a linker region, and a cysteine-rich C-terminal domain. DNAJC5B is a paralog of DNAJC5 (CSPα), but unlike DNAJC5, it lacks robust evidence for involvement in any specific disease or recognized therapeutic modulation. Its main function, inferred from orthologs and structure, is general protein homeostasis through chaperone regulation, rather than direct involvement in cell signaling or disease mechanisms.\nDNAJC5 (CSPα) is associated with neurodegenerative disease (e.g., neuronal ceroid lipofuscinosis), but DNAJC5B ("beta" variant) does not share these direct associations based on current knowledge and data.\nThe name and sequence details you provided are accurate and correspond to a recognized human gene/protein.

Other names

DnaJ (Hsp40) homolog, subfamily C, member 5 betaCSP-betaMGC26226Cysteine-string protein isoform betadnaJ homolog subfamily C member 5BTHE1B/DNAJC5B.1beta cysteine string proteinbeta-CSPcysteine string protein betatesticular tissue protein Li 55