DnaJ heat shock protein family member C8 (DNAJC8)

DnaJ heat shock protein family member C8 (DNAJC8) is a co-chaperone protein belonging to the heat shock protein 40 (HSP40) family, specifically the DNAJ subfamily C. DNAJC8 is involved in several cellular processes, including regulation of the spliceosome, nucleocytoplasmic transport, and cell cycle progression. Elevated expression of DNAJC8 has been observed in hepatocellular carcinoma (HCC) and is associated with poor prognosis, advanced tumor stage, and vascular invasion. Functional studies demonstrate that DNAJC8 promotes cancer cell proliferation and inhibits apoptosis, likely through mechanisms involving the cell cycle and interaction with the TP53 pathway. Additionally, high DNAJC8 levels correlate with immune suppression within the tumor microenvironment by modulating immune cell infiltration and checkpoint expression. Its critical role in oncogenesis and tumor progression makes DNAJC8 a potential prognostic marker and therapeutic target, particularly in HCC[1][2].

Other names

DnaJ homolog subfamily C member 8SPF31HSPC315HSPC331Splicing protein spf31dnaJ homolog subfamily C member 8DnaJ (Hsp40) homolog, subfamily C, member 8splicing protein spf31

Inhibition of DNAJC8 (e.g., by knockdown) suppresses cancer cell proliferation and induces apoptosis[1][2]. DNAJC8 is involved in the formation of immunosuppressive tumor microenvironment, possibly by regulating immune checkpoints and cell infiltration[1][2].