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DnaJ homolog subfamily B member 12 (DNAJB12)
- Target
- DNAJB12
- Molecular classification
- Heat shock protein (Hsp40 family), Co-chaperone, Endoplasmic reticulum-associated protein (ER-resident chaperone)
01
Overview
DnaJ homolog subfamily B member 12 (DNAJB12) is an ER-localized Hsp40 co-chaperone that recruits Hsp70 to the ER surface to facilitate protein folding, triage, and degradation processes. It contains an N-terminal J-domain, a transmembrane domain, and a stress-sensitive DUF1977 domain, making it important for regulating ER homeostasis, especially under conditions of proteotoxic stress. DNAJB12 is important for the constitutive degradation of BOK, a pro-apoptotic BCL-2 family protein, thereby functioning as an ER stress sensor and influencing cell survival and apoptosis
- Other names
- DnaJ heat shock protein family (Hsp40) member B12JB12DNAJ/HSP40 family member B12
02
Biological functions
Protein foldingProtein traffickingPrevention of protein aggregationER stress responseRegulation of apoptosis (through BOK suppression)
03
Disease associations
Cancer (regulates apoptosis and response to chemotherapeutics)Other (ER stress-related pathologies; evidence for involvement in proteostasis diseases)
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