DnaJ homolog subfamily C member 2 (DNAJC2)

DnaJ homolog subfamily C member 2 (DNAJC2) is a multifunctional protein belonging to the heat shock protein 40 (Hsp40) family, specifically the M-phase phosphoprotein (MPP) family, characterized by a J domain and a Myb-type DNA-binding domain[1][3][4]. It functions as both a molecular chaperone—where it forms heterodimers with ribosome-associated complexes to aid the folding and maturation of nascent polypeptides—and a chromatin regulator, with roles in transcriptional activation by binding ubiquitinated histone H2A to displace Polycomb repressive complexes, thus facilitating activation of tumor suppressor genes[1][3][5]. DNAJC2 acts in both the nucleus and cytosol, is essential during embryonic development, and has been linked to several cancers and proliferative disorders, with upregulation in leukemic blasts and colorectal cancer among others[1][3][4][5]. Dysregulation of DNAJC2 has been associated with oncogenic processes, and the gene is considered a potential therapeutic target as well as a biomarker for certain malignancies[1][3].\n\nNo approved drugs or direct small-molecule inhibitors targeting DNAJC2 are documented in open sources[3][4], and established mechanisms of pharmacological modulation have not been described.\n\nIf you need more details (such as specific list of interacting proteins or further disease associations), please specify.

Other names

ZRF1MPP11MPHOSPH11ZUO1Zuotin-related factor 1M-phase phosphoprotein 11DnaJ heat shock protein family member C2