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Target intelligence / Profile preview
DNAJC27 antisense RNA 1 (DNAJC27-AS1)
- Target
- DNAJC27-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA, Non-coding RNA, Not a protein, enzyme, transporter, or receptor
01
Overview
DNAJC27 antisense RNA 1 (DNAJC27-AS1) is a human long non-coding RNA gene expressed from chromosome 2, acting as an antisense transcript that negatively regulates the expression of DNAJC27—a protein-coding gene implicated in cellular stress responses and metabolic regulation[7][5][1][10]. DNAJC27-AS1 does not encode a protein and is affiliated with regulatory RNA functions, particularly in modulation of gene expression[7][5]. Disease-association data suggest links to glioma and glaucoma, but mechanistic details and translational relevance remain limited[10]. There is no current evidence for direct drug interaction or use as a validated biomarker[8][10].
- Other names
- DNAJC27-AS1DNAJC27 antisense RNA 1 (non-protein coding)ENSG00000224165 (Ensembl gene ID)NCBI Gene ID: 729723GC02P025196 (previous GeneCards ID)
02
Mechanism of action
Not applicable; no known drugs or small molecules modulate DNAJC27-AS1 directly.
03
Biological functions
Negative regulation of DNAJC27 gene expressionMay contribute to post-transcriptional regulation via RNA interference or epigenetic mechanismsNo evidence for direct involvement in canonical signaling, cell cycle, apoptosis, or other classical pathways.
04
Disease associations
Associated with susceptibility to gliomaAssociated with primary open angle glaucoma
05
Safety considerations
Not applicable; no current interventions targeting DNAJC27-AS1
06
Biomarkers
Not established as a clinical biomarker for patient selection or efficacy; potential research interest in cancer and glaucoma contexts
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