DNL-type zinc finger protein (Hsp70-escort protein 1) (DNLZ)

DNL-type zinc finger protein (abbreviated DNLZ, also known as TIMM15, HEP1, ZIM17, mtHsp70-escort protein, and several other aliases) is a mitochondrial protein featuring a zinc finger-like motif. Unlike classical zinc finger transcription factors, DNLZ is not known to bind DNA or RNA nor to act in signal transduction, but rather functions as a chaperone/escort that regulates the activity, folding, and import of mitochondrial Hsp70 proteins. The protein is essential for mitochondrial protein homeostasis, but it is not an enzyme, transporter, channel, or receptor, nor is it yet recognized as a therapeutic target or biomarker. Many aliases exist because of separate identification in different species (e.g. yeast, human), sequence annotation projects, and functional studies; all refer to the same class of mitochondrial proteins involved in Hsp70 regulation and protein import machinery. No disease associations, drug interactions, or therapeutic developments have been described for this protein.

Other names

TIMM15DNLZHEP1ZIM17mtHsp70-escort proteinHsp70-escort protein 1C9orf151RP11-413M3.2bA413M3.2Translocase of inner mitochondrial membrane 15 homolog (yeast)HSP70 escort protein

None known; as no drugs are documented to interact, mechanism of action is not applicable.