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DOCK1 antisense RNA 1 (DOCK1-AS1)

Target: DOCK1-AS1
Molecular classification: Long non-coding RNA (lncRNA), Antisense RNA, Other

Overview

DOCK1 antisense RNA 1 (DOCK1-AS1) is a long non-coding RNA (lncRNA) that is transcribed in antisense orientation relative to the DOCK1 gene and is classified as an antisense lncRNA. Antisense lncRNAs such as DOCK1-AS1 typically regulate their sense gene (here, DOCK1) post-transcriptionally or epigenetically, including by influencing mRNA stability, modulating translation, or recruiting chromatin-modifying complexes to the corresponding gene locus. While the specific mechanistic and disease associations for DOCK1-AS1 are poorly characterized in current literature, functionally similar antisense lncRNAs are often implicated in the regulation of gene expression programs relevant to cell proliferation, migration, and oncogenesis. No direct evidence was found that DOCK1-AS1 itself is a therapeutic target, interacts with drugs, or serves as a clinical biomarker; these roles are currently more strongly established for its sense protein-coding counterpart, DOCK1.

Other names: DOCK1-AS1Dock1 antisense RNA 1lnc-DOCK1-2DOCK1 Antisense RNA 1

Biological functions

Gene expression regulationEpigenetic regulationRegulation of mRNA stabilityModulation of cell proliferationModulation of cell migrationOther

Disease associations

Cancer (esp. bladder, prostate; based on general functions of antisense lncRNAs and docking analogs)Possibly other (e.g., atherosclerosis by analogy with NCK1-AS1)

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