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DOCK8 antisense RNA 1 (DOCK8-AS1)

Target: DOCK8-AS1
Molecular classification: Long non-coding RNA (lncRNA), Non-coding RNA (ncRNA), Long intergenic non-coding RNA (lincRNA)

Overview

DOCK8 antisense RNA 1 (DOCK8-AS1) is a long non-coding RNA (lncRNA), classified as a long intergenic non-coding RNA (lincRNA) and non-coding RNA (ncRNA)[6][7][8]. It is encoded on human chromosome 9 (NCBI Gene ID: 157983) and is transcribed but not translated into a protein[6][7]. The precise biological functions of DOCK8-AS1 are currently uncharacterized, and there is little to no experimental evidence supporting a direct role in cellular pathways or disease mechanisms[7][6]. Diseases listed in association with DOCK8-AS1, such as combined immunodeficiency and Hyper-IgE syndrome, likely reflect its genomic proximity to the protein-coding gene DOCK8, which is directly implicated in these disorders[7]. DOCK8-AS1 is not recognized as a therapeutic target, receptor, enzyme, transporter, or similar effector molecule, and there are no known drugs, mechanisms of action, biomarkers, or specific safety concerns related to this non-coding RNA[7][6][8].

Other names: C9orf66FLJ31158Uncharacterized protein DOCK8-AS1DOCK8 antisense RNA 1DOCK8-AS1

Biological functions

UnknownOther (no specific biological function has been experimentally confirmed)

Disease associations

Combined immunodeficiency (associative, not as a causative agent)Hyper-IgE syndrome (associative)

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