DOCK9 divergent transcript (DOCK9-DT)

DOCK9 divergent transcript (DOCK9-DT) is a long non-coding RNA (lncRNA) gene located on human chromosome 13q32.3, transcribed in a divergent orientation from the DOCK9 protein-coding gene. The term "divergent transcript" reflects its transcriptional start site being closely positioned (~bidirectionally) to the DOCK9 gene promoter, commonly found among lncRNAs that may have regulatory effects on their paired coding genes. There is currently no evidence that DOCK9-DT encodes a protein or is a therapeutic target. Its functional or regulatory roles, particularly in disease, remain uncharacterized, but it may play a role in fine-tuning transcription at developmental and regulatory loci, similar to other divergent lncRNAs[1][3][4][7][11]. The nearby DOCK9 gene encodes a guanine nucleotide exchange factor involved in Rho GTPase signaling and has roles in cytoskeletal dynamics and cell signaling[2][5][9]. DOCK9-DT is not to be confused with DOCK9 and has distinct biological categorization. DOCK9-DT is a divergent lncRNA with a poorly characterized function, not a canonical therapeutic target, and best described as a transcript predominantly relevant for genomic regulation rather than pharmacologic intervention[1][3][4][7][11].

Other names

DOCK9-AS2