Dolichyl-phosphate mannosyltransferase subunit 3 (DPM3)

Dolichyl-phosphate mannosyltransferase subunit 3 (DPM3) is a regulatory and stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex, a critical multi-protein enzyme in the endoplasmic reticulum required for synthesis of dolichol-phosphate mannose, an essential glycosyl donor for N-glycosylation and the production of glycosylphosphatidylinositol (GPI) anchors. The DPM3 protein tethers the catalytic subunit (DPM1) to the endoplasmic reticulum membrane. Disruption of DPM3 function impairs glycoprotein biosynthesis, leading to congenital disorders of glycosylation and certain forms of muscular dystrophy[1][2][8].

Other names

Dolichyl-phosphate mannosyltransferase polypeptide 3Dolichyl-phosphate beta-D-mannosyltransferase subunit 3Dolichol-phosphate mannosyltransferase subunit 3Dolichol-phosphate mannose synthase subunit 3Mannose-P-dolichol synthase subunit 3DPM synthase subunit 3MPD synthase subunit 3MGC125904[2]

No approved or investigational drugs are described to act by targeting this molecule; mechanism relates to its biological enzymatic and stabilizer role