Dolichyldiphosphatase 1 (DOLPP1)

Dolichyldiphosphatase 1 is an enzyme located in the endoplasmic reticulum that hydrolyzes dolichyl pyrophosphate (Dol-P-P) to dolichyl phosphate (Dol-P), furnishing a key step for the recycling and maintenance of dolichol lipids required for proper N-glycosylation in eukaryotic cells. This enzymatic activity is necessary to maintain optimal levels of dolichol-linked oligosaccharides, thus enabling efficient glycoprotein biosynthesis. Mutations in DOLPP1 are implicated in congenital disorders of glycosylation, underscoring its essential role in protein processing and cell function.

Other names

DOLPP1Dolichyl pyrophosphate phosphatase 1DOPP1

Not applicable; the enzyme is mainly a biosynthetic regulator of dolichol metabolism and N-glycosylation, with no established drug inhibitors/modulators