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Target intelligence / Profile preview
DOPA Decarboxylase (AADC)
- Target
- AADC
- Molecular classification
- Enzyme, Pyridoxal phosphate-dependent enzyme
01
Overview
DOPA decarboxylase, also known as aromatic L-amino acid decarboxylase (AADC), is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the decarboxylation of L-DOPA to dopamine and L-5-hydroxytryptophan to serotonin. These reactions are critical steps in the biosynthesis of key neurotransmitters and the enzyme is a therapeutic target for neurological disorders such as Parkinson's disease. Inhibitors like carbidopa are used to modulate the peripheral conversion of levodopa.
- Other names
- Aromatic L-amino acid decarboxylaseDDC
02
Mechanism of action
Inhibits peripheral decarboxylation of levodopa, increasing the amount of levodopa available to cross the blood-brain barrier for conversion to dopamine in the brain.
03
Biological functions
Neurotransmitter synthesisDopamine productionSerotonin productionCatecholamine biosynthesis
04
Disease associations
Aromatic L-amino acid decarboxylase deficiencyParkinson’s diseaseSchizophreniaDepressionBipolar affective disorderProstate cancerNeurodegenerative diseaseNeurological disorders
05
Safety considerations
Potential side effects associated with altered dopamine and serotonin levelsDrug interactions with inhibitors of DDC
06
Interacting drugs
Carbidopa
1 more in the full profile.
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