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Target intelligence / Profile preview
DOPA Decarboxylase (Peripheral) (DDC)
- Target
- DDC
- Molecular classification
- Enzyme, Lyase, Pyridoxal phosphate-dependent enzyme
01
Overview
DOPA decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase (AADC), is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the decarboxylation of L-DOPA to dopamine and L-5-hydroxytryptophan to serotonin. The peripheral form refers to its activity outside the central nervous system. Peripheral DDC is targeted by inhibitors like carbidopa and benserazide to enhance levodopa's efficacy in treating Parkinson's disease by preventing its premature conversion to dopamine in the periphery, reducing side effects and increasing CNS availability.
- Other names
- Aromatic L-amino acid decarboxylaseAADCAAAD
02
Mechanism of action
Inhibition of peripheral DOPA decarboxylase, preventing the conversion of L-DOPA to dopamine outside the brain.
03
Biological functions
CatalysisDopamine synthesisSerotonin synthesisCatecholamine synthesisNeurotransmitter synthesisImmune regulation
04
Disease associations
Parkinson's diseaseNeurodegenerative diseaseImmune disorders
05
Safety considerations
Peripheral side effects of dopamine (nausea, vomiting, hypotension)Reduced CNS availability of L-DOPA if not co-administered with a peripheral DDC inhibitor
06
Interacting drugs
Levodopa
2 more in the full profile.
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