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Target intelligence / Profile preview
Tyrosinase-related Protein 2 (TRP2)
- Target
- TRP2
- Molecular classification
- Enzyme, Melanocyte differentiation antigen
01
Overview
Tyrosinase-related protein 2 (TRP2), also known as DOPAchrome tautomerase (DT), is a melanocyte differentiation antigen and an enzyme crucial for melanin biosynthesis in mammals. It catalyzes the conversion of DOPAchrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA), thereby influencing both the quantity and quality of melanin produced. TRP2 acts as a tumor-associated antigen recognized by cytotoxic T lymphocytes (CTLs) in melanoma models and is a target for immunotherapy.
- Other names
- DOPAchrome tautomeraseDT
02
Mechanism of action
Immunotherapy target; peptide epitopes used to stimulate anti-tumor T cell responses
03
Biological functions
Melanogenesis regulationPigment type determinationDOPAchrome isomerization
04
Disease associations
CancerMelanoma
05
Biomarkers
TRP2 expression in melanoma cells
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