Dopamine D1-like receptor family (D1-like receptors)

The D1-family dopamine receptors, comprising the D1 and D5 subtypes, are a class of G protein-coupled receptors (GPCRs) that play a fundamental role in the central nervous system and peripheral tissues (UniProt, 2023). These receptors are characterized by their coupling to stimulatory G proteins (Gs/olf), which activate adenylyl cyclase to increase intracellular cAMP levels, thereby modulating neuronal excitability and synaptic plasticity (StatPearls, 2024). In the brain, they are heavily involved in regulating motor activity, executive functions, and reward-related behaviors, while in the periphery, they contribute to the regulation of blood pressure and renal function (IUPHAR/BPS, 2023). Dysregulation of D1-family signaling is implicated in several neuropsychiatric and neurological conditions, including Parkinson's disease, schizophrenia, and ADHD (PubMed, 2022). Pharmacological targeting of these receptors involves agonists like fenoldopam for treating hypertension, as well as antagonists, often as part of a broader antipsychotic profile, to manage psychotic symptoms (PubChem, 2024). Understanding the distinct expression patterns and functional roles of D1 and D5 receptors remains a key area of research for developing more selective and effective therapeutic interventions (NIH, 2023).

Other names

D1-like dopamine receptorsD1-family receptorsD1 and D5 receptorsDRD1DRD5

D1-family receptors primarily couple to Gs or Golf proteins, which stimulate adenylyl cyclase activity, leading to an increase in the second messenger cyclic adenosine monophosphate (cAMP) and subsequent activation of protein kinase A (PKA) (StatPearls, 2024).