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Dopamine D1 Receptor (D1R)
- Target
- D1R
- Molecular classification
- G protein-coupled receptor, GPCR rhodopsin family, Receptor
01
Overview
The dopamine D1 receptor (D1R) is a member of the G protein-coupled receptor (GPCR) family, specifically classified within the D1-like subfamily. It is the most abundant dopamine receptor subtype in the central nervous system and plays a key role in regulating motor behavior, reward processing, motivation, memory formation, learning, attention, impulse control, and neuronal development. Dysfunctional signaling is associated with neuropsychiatric disorders such as Parkinson’s disease (PD), schizophrenia, Huntington's disease, attention deficit hyperactivity disorder (ADHD), cognitive impairment disorders—and plays a role in addiction mechanisms. The D1R is an established therapeutic target for CNS diseases including PD.
- Other names
- Dopamine D(1A) ReceptorDopamine Receptor D1
02
Mechanism of action
Activation stimulates adenylyl cyclase via Gαs/olf coupling, increasing intracellular cAMP levels and activating protein kinase A (PKA).
03
Biological functions
Signal transductionRegulation of motor behaviorReward processingMotivationMemory formationLearningAttentionImpulse controlNeuronal developmentModulation of synaptic activity
04
Disease associations
ParkinsonismHypertensionAllergic/hypersensitivity disorderAbortionParkinson’s diseaseSchizophreniaHuntington's diseaseAttention deficit hyperactivity disorderCognitive impairment disordersAddiction
05
Safety considerations
Side effects related to dopaminergic therapies
06
Interacting drugs
L-DOPA
2 more in the full profile.
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