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Target intelligence / Profile preview
Dopamine D2 Receptor (D2R)
- Target
- D2R
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor, Dopamine receptor
01
Overview
The dopamine D2 receptor (D2R) is a G protein-coupled receptor that plays a crucial role in numerous central nervous system functions. It is a primary target for antipsychotic drugs and is involved in movement, cognition, emotion, reward processing, and neuroendocrine regulation. It exists in long and short isoforms, with the short isoform acting as a presynaptic autoreceptor.
- Other names
- DRD2D2 dopamine receptor
02
Mechanism of action
Antagonism (antipsychotics); Agonism (Parkinson's disease)
03
Biological functions
Signal transductionNeurotransmissionRegulation of dopamine synthesis and releaseModulation of neuronal excitabilityRegulation of locomotionRegulation of motivation and rewardLearning and memory
04
Disease associations
SchizophreniaPsychosisParkinson's diseaseDrug addictionSubstance use disorders
05
Safety considerations
Motor side effects (e.g., extrapyramidal symptoms) with antipsychoticsTardive dyskinesiaNeuroleptic malignant syndrome
06
Interacting drugs
Antipsychotics (typical and atypical)
1 more in the full profile.
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