Dopamine D2 receptor and Serotonin 5-hydroxytryptamine receptor 1A (D2 receptor (for Dopamine D2 receptor), 5-HT1A receptor (for Serotonin 5-HT1A receptor))

Dopamine D2 receptor and Serotonin 5-HT1A receptor are both G protein-coupled receptors (GPCRs) highly expressed in the mammalian brain, playing key roles in neurotransmission and neuropsychiatric processes. D2 receptors primarily mediate dopaminergic signaling, regulating movement, motivation, and reward, and are the main target for antipsychotic drugs. 5-HT1A receptors mediate serotonin signaling, impacting mood, anxiety, and cognition, and are targets for anxiolytics and some antidepressants. Recent studies show these receptors can form heterodimers with unique biochemical and functional properties, which may represent novel targets for improved neuropsychiatric therapy[3][6][5]. These receptors are widely distributed in the brain and periphery, can be visualized in vivo with specific PET radioligands, and are involved in both normal physiology and the pathophysiology of disorders such as schizophrenia, depression, and Parkinson’s disease[1][2][6].

Other names

D2 receptorDRD25-HT1A receptorHTR1A

Dopamine D2 receptor: antagonism or partial agonism (as with most antipsychotics, which block D2-mediated signaling); Serotonin 5-HT1A receptor: agonism or partial agonism (as with buspirone or aripiprazole, stimulating 5-HT1A and mediating anxiolytic/antidepressant effects); For heteromers: potentially unique, not fully elucidated.