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Target intelligence / Profile preview
Dopamine D2L Receptor (D2L receptor)
- Target
- D2L receptor
- Molecular classification
- G protein-coupled receptor, GPCR, Dopamine receptor, D2-like receptor family
01
Overview
The dopamine D2L receptor is a G protein-coupled receptor isoform encoded by the *DRD2* gene. It is predominantly postsynaptic and highly expressed in the striatum. Activation of D2L receptors leads to inhibition of adenylyl cyclase and decreased cAMP levels, playing a key role in motor control, reward processing, learning, and memory. It is a major target for antipsychotic drugs, and its dysfunction is implicated in neuropsychiatric disorders like schizophrenia and affective disorders.
02
Mechanism of action
Gi/o protein-coupled receptor agonist; inhibits adenylyl cyclase/cAMP production
03
Biological functions
Signal transductionMotor activity regulationReward processingLearningSynaptic plasticityMemory formationHormonal control
04
Disease associations
SchizophreniaAffective disorders
05
Safety considerations
Extrapyramidal symptoms (EPS)Tardive dyskinesiaCatalepsy
06
Interacting drugs
Antipsychotics
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