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Target intelligence / Profile preview
Dopamine D5 Receptor (DRD5)
- Target
- DRD5
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The Dopamine D5 receptor (DRD5) is a subtype of dopamine receptor belonging to the D1-like family. It is a G-protein coupled receptor that activates adenylyl cyclase, leading to increased cAMP production. DRD5 plays a role in regulating attention, mood, memory, learning, movement, and cognitive processes, particularly working memory. It is a potential therapeutic target for neuropsychiatric disorders and chronic pain, although the development of selective ligands remains a challenge.
- Other names
- D5 receptor
02
Mechanism of action
Activation leads to stimulation of adenylyl cyclase → increased cAMP → downstream signaling cascades affecting neuronal excitability.
03
Biological functions
Signal transductionRegulation of attentionModulation of moodRegulation of memoryRegulation of learningRegulation of movementWorking memoryCognitive processesNeurotransmission
04
Disease associations
SchizophreniaBipolar disorderADHDParkinson’s disease (cognitive symptoms)Chronic pain
05
Safety considerations
Lack of highly selective agonists and antagonists may lead to off-target effects.
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