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Target intelligence / Profile preview
Dopamine Receptor D1 Subtype (DRD1)
- Target
- DRD1
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The dopamine receptor D1 (DRD1) is a G protein-coupled receptor and a member of the dopamine receptor family. It is the most abundant dopamine receptor in the central nervous system and plays key roles in reward processing, motor control, and cognitive functions. DRD1 primarily couples to Gαs/olf, leading to stimulation of adenylyl cyclase and increased cAMP levels. Dysfunctional DRD1 signaling has been implicated in neuropsychiatric disorders such as Parkinson’s disease, schizophrenia, and ADHD. Current pharmacotherapies targeting this pathway focus on PD and cognitive impairment but also play roles indirectly via drugs like L-DOPA.
- Other names
- D1 receptorDopamine receptor D1
02
Mechanism of action
Activation of adenylyl cyclase leading to increased intracellular cAMP levels
03
Biological functions
Signal transductionReward system modulationMotor activity regulationMemory formationLearning processesNeuronal development
04
Disease associations
Parkinson’s diseaseSchizophreniaHuntington's diseaseAttention deficit hyperactivity disorderAddiction
05
Safety considerations
Lack of fully selective ligands over DRD5Potential for off-target effects due to widespread distribution in the brain
06
Interacting drugs
SKF38393
3 more in the full profile.
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