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Target intelligence / Profile preview
Dopamine Receptor D1A (DRD1)
- Target
- DRD1
- Molecular classification
- GPCR, Dopamine Receptor, G protein-coupled receptor, D1-like subfamily
01
Overview
Dopamine receptor D1A (DRD1) is a G protein-coupled receptor that belongs to the D1-like subfamily of dopamine receptors. It is primarily coupled to Gs/olf proteins, leading to activation of adenylyl cyclase and increased cAMP production. DRD1 is highly expressed in the striatum and plays a critical role in regulating memory, learning, reward processing, locomotor activity, and motivation. Dysfunctional DRD1 signaling has been implicated in several neurological disorders including Parkinson’s disease, schizophrenia, ADHD, and addiction.
- Other names
- D1 receptorDopamine receptor type 1
02
Mechanism of action
Gs/olf protein coupling, activation of adenylyl cyclase, increased cAMP production, PKA activation, DARPP-32 phosphorylation.
03
Biological functions
Signal transductionMemory regulationLearning regulationReward processingLocomotor activity regulationMotivation regulationMood regulationCognitive functionNeurodevelopmental processesNeuronal growth
04
Disease associations
Parkinson’s diseaseSchizophreniaHuntington's diseaseAttention deficit hyperactivity disorder (ADHD)Substance use disorders/addiction
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