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Target intelligence / Profile preview
Dopamine Receptor D2 (DRD2)
- Target
- DRD2
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
Dopamine receptor D2 (DRD2) is a G protein-coupled receptor that plays a central role in the dopaminergic system of the brain. It is encoded by the *DRD2* gene. DRD2 is one of five dopamine receptor subtypes and belongs to the "D2-like" family. It regulates locomotion, cognition, emotion, and neuroendocrine secretion. Most antipsychotic drugs act as antagonists at DRD2. Dysregulation of DRD2 signaling is linked to schizophrenia, Parkinson’s disease, and substance use disorders.
- Other names
- D2 dopamine receptorD2RDRD2 long formDRD2 short form
02
Mechanism of action
Antagonism or partial agonism at the dopamine D2 receptor.
03
Biological functions
Regulation of dopamine synthesisRegulation of dopamine releaseRegulation of dopamine reuptakeModulation of neuronal excitabilityModulation of neurotransmitter releaseSignal transductionLocomotionCognitionEmotionAffective state regulationNeuroendocrine secretionSynaptic plasticityMemory formationCognitive flexibility
04
Disease associations
SchizophreniaParkinson's diseaseSubstance use disorders
05
Safety considerations
Extrapyramidal symptoms (EPS)Tardive dyskinesiaWeight gainMetabolic syndromeHyperprolactinemia
06
Interacting drugs
Antipsychotics
1 more in the full profile.
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