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Target intelligence / Profile preview
Dopamine Receptor D2 Long Isoform (D2L)
- Target
- D2L
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
Dopamine receptor D2L is a G protein-coupled receptor and one of two major isoforms produced by alternative splicing of the DRD2 gene. Predominantly postsynaptic, D2L modulates motor activity, cognition, and emotion. As the main target for antipsychotic medications, it plays a key role in treating schizophrenia and other dopamine-related disorders. Dysfunction or genetic variation within D2L contributes to diseases such as Parkinson’s disease and addiction.
- Other names
- DRD2-LD2 long isoformDopamine D2L receptorDrd2-LD₂-Lh
02
Mechanism of action
Antagonism or agonism at the D2L receptor to modulate dopaminergic signaling
03
Biological functions
Signal transductionMotor control regulationCognitionEmotion regulationSynaptic plasticityMemory formationModulation of neuronal firingNeurotransmitter release
04
Disease associations
SchizophreniaParkinson’s diseaseDrug addictionPsychosis
05
Safety considerations
Extrapyramidal symptoms (EPS) with antipsychoticsTardive dyskinesiaNeuroleptic malignant syndrome (NMS)
06
Interacting drugs
Haloperidol
4 more in the full profile.
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