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Dopamine receptor D2 subtype (DRD2)
- Target
- DRD2
- Molecular classification
- G protein-coupled receptor, GPCR, Class A GPCR, Rhodopsin-like GPCR, Receptor
01
Overview
The dopamine receptor D2 subtype (DRD2) is a member of the dopamine receptor family, which are G protein-coupled receptors (GPCRs) involved in mediating the physiological actions of dopamine, a key neurotransmitter in the central nervous system. DRD2 is encoded by the DRD2 gene in humans. It plays a critical role in motor control, reward, motivation, and cognition. As an autoreceptor, it regulates dopamine synthesis, release, and uptake. DRD2 is a primary target for antipsychotic drugs, with antagonism at this receptor underlying both therapeutic effects against psychosis and side effects such as extrapyramidal symptoms. Isoforms include long (D2L) and short (D2S) forms, with differing localization and function.
- Other names
- D2 dopamine receptorDopamine D2 receptorDRD2 receptor
02
Mechanism of action
Antagonism at DRD2 receptors; Agonism at DRD2 receptors
03
Biological functions
Signal transductionModulates motor control pathwaysReward processingMotivationCognitionLearningMemoryRegulation of dopamine synthesisRegulation of dopamine releaseRegulation of dopamine uptake
04
Disease associations
SchizophreniaPsychosisParkinson's disease
05
Safety considerations
Extrapyramidal symptoms (EPS) due to DRD2 antagonism
06
Interacting drugs
Bromocriptine
2 more in the full profile.
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